Welcome and Introduction
Joseph Graziano, Committee Chair |
Play Flash Video
|
|
Update on EPA’s Inorganic Arsenic Activities
Kenneth Olden and Vincent Cogliano, U.S. Environmental Protection Agency |
Play Flash Video
|
|
Strengths and Weaknesses of Recent Epidemiologic Studies of Inorganic Arsenic
Cancer Evidence and Dose-Response Relationships
Kenneth Cantor, National Cancer Institute
Noncancer Evidence and Dose-Response Relationships
Craig Steinmaus, California Environmental Protection Agency, University of
California at Berkeley |
Play Flash Video
|
|
Integration of Metabolism and Mode of Action Information in Hazard Identification and Dose-Response Analyses - Part 1
Metabolism, Its Consequences, and Implications for Low Dose Assessments
David Thomas, U.S. Environmental Protection Agency
Mode of Action and Mechanism Identification and Implications for Low Dose
Assessments
Samuel Cohen, University of Nebraska Medical Center
Interplay Between One-carbon Metabolism, Arsenic Metabolism and Epigenetics
Mary Gamble, Columbia University |
Play Flash Video
|
|
Integration of Metabolism and Mode of Action Information in Hazard Identification and Dose-Response Analyses - Part 2
Mode of Action for Lung and Cardiovascular Effects
R. Clark Lantz, University of Arizona
Impact of In Utero and Whole Life Exposure and Implications for Dose Response
Michael Waalkes, National Institute for Environmental Health Sciences |
Play Flash Video
|
|
Integration of Metabolism and Mode of Action Information in Hazard Identification and Dose-Response Analyses - Panel Discussion
Moderators: Aaron Barchowsky and Rebecca Fry
1. Are there data that support low dose mechanisms and modes of action?
2. Is there a continuum of common thread in cancer and noncancer
mechanisms and modes of action?
3. Are there gender and species differences in metabolism or modes of action
that impact dose response and disease susceptibility?
4. Do the kinetics and dynamics of inorganic arsenic and its metabolites in
different organs promote organ-specific disease? |
Play Flash Video
|
|
Probabilistic Dose-Response and Harmonization Approaches for Cancer and Noncancer Effects
- Lessons Learned from Lead and Particulate Matter
Joel Schwartz, Harvard School of Public Health
- Extrapolation of Mode of Action Data to Dose-Response Modeling of Human
Health End Points
Harvey Clewell, The Hamner Institutes of Health Sciences
Panel Discussion:
Moderators: Gary Ginsberg and Robert Wright
Discussant: Daniel Axelrad, U.S. Environmental Protection Agency
1. Do the available gene expression data define a coherent mechanism for
cancer and noncancer effects?
2. Do these data adequately describe the array of effects at low dose?
3. How might the mode of action based dose response be affected by
population variability?
4. How would one construct a probabilistic assessment of noncancer dose
response from which the probability of an adverse effect can be estimated at
any dose?
5. What are the implications of mode of action based and probabilitstic-based
assessments for risk-benefit analysis? |
Play Flash Video
|
|
Risk Assessment Approaches and Application of IRIS Values
- Systematic Review and Evidence Integration for Literature-Based
Environmental Health Assessments
Andrew Rooney, U.S. National Toxicology Program
- Perspectives of Risk Assessors and Users of IRIS Values
Question: Given your experience in risk assessment activities, what aspects of
the Toxicological Review of Inorganic Arsenic would be critical for
maximizing the utility and credibility of the review for the risk assessments that
you undertake?
Barbara Beck, Gradient Corporation
Michael Hansen, Consumers Union
Joyce Tsuji, Exponent, Inc.
Kate Sande, Minnesota Department of Health |
Play Flash Video
|
|
Risk Assessment Approaches and Application of IRIS Values - Panel Discussion
Moderators: Sandra Baird and Hugh Barton
Question 1: Joyce Tsuji and Michael Hansen
1a. “Science and Decisions” (NRC 2009) recommended that EPA adopt a
unified dose-response assessment framework for cancer and noncancer end
points. It has been suggested that an arsenic IRIS assessment might provide:
a. Risk estimates for noncancer end points (rather than or in addition to a
concentration assumed to be health protective, such as an RfD)
b. Nonlinear cancer assessment
c. Multiple risk estimates for a single toxicity end point (e.g., alternative
mode of action hypotheses, estimates from different studies, multiple
dose-response models fitted to the same data)
d. Risk estimates for many toxicity end points
What recommendations do you have for EPA on use of these approaches?
1b. If the toxicological review of inorganic arsenic contains risk estimates
derived from the dose-response approaches described in Question 1a, how
would that impact the practice of risk assessment in the activities you are
involved in?
Question 2: Barbara Beck and Kate Sande
2a. EPA has been asked by stakeholders to explicitly include consideration of
populations that may have increased susceptibility to the adverse effects from
arsenic (e.g., life stages, genetics, pre-existing disease, and environmental
stressors such as co-exposures and nutritional deficiencies). What type of
quantitative estimates of susceptibility would be useful in your risk assessment
activities? If quantitative estimates cannot be derived, how do you recommend
EPA provide information on susceptibility so that it can be used to inform your
risk assessment activities?
2b. What types of documentation (and level of detail) are necessary to assist
you and other users of an IRIS assessment if one of these approaches (which are
not currently standard methods) were used?
Additional Questions for Workshop Speakers and Panelists from Committee |
Play Flash Video
|
|
Public Comments
Lorenz R. Rhomberg, Ph.D., FATS | Gradient Corporation
Steven H. Lamm, MD, DTPH, FAAP, FACOEM, FACE | Consultants in Epidemiology and Occupational Health, LLC |
Play Flash Video
|
|
|