it is well known that there is a range of human
susceptibility to effects of given environmental
exposures. This range is due in part to endogenous
factors such as genetics and epigenetics, physiology,
lifestage, and other biological differences.
Variability in
individual exposures also contributes significantly to
variability in human susceptibility, but this workshop
focuses on the endogenous/biological factors.
The 2010 National Research Council report Science
and Decisions: Advancing Risk Assessment notes that it
is difficult to estimate an average population risk without
understanding how the risk varies among individuals in
the population. However, the default approach in risk
assessment to account for individual variability is to
assume that a ten-fold decrease in allowable exposure
will protect the most sensitive subpopulations, even
though seldom it is known whether such approach may
be overprotective or insufficient.
Emerging Molecular Techniques, such as next
generation sequencing, are advancing scientists' ability
to characterize how individuals differ inherently (genetically
and otherwise). Such information can also be used
to predict how such individual differences may affect
one's susceptibility to a given exposure. While it may
not be feasible to determine susceptibility of each individual
to each potential exposure, clearly we can
characterize the range and a distribution of biological
variability in humans at a more granular level than
assuming a ten-fold uncertainty factor.
This workshop will explore new and innovative
approaches to characterizing individual variability
arising from endogenous/biological factors and its impact
on susceptibility to risks from environmental exposures.
Discussions will also delve into how to bring new data
collection and analytic approaches to bear and layer
them with conventional data on variability. Topics will
span a range of approaches, from molecular analyses to
the use of human cells and animal models as experimental
systems, and how these approaches can be used
to better characterize individual variability linked to
endogenous factors in toxicity, epidemiology, and
genome-wide-association studies.
The workshop will also consider the implications
of emerging approaches to policies
designed to address susceptibility in public health and
risk assessment. Workshop participants will address
approaches for and challenges to describing the relationships
among individual variability, disease susceptibility,
and public health.
Some questions that will be used to guide the workshop
discussions include the following:
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What are the current and emerging technologies
that can better inform us about the distribution of
individual variability within a population that are
due to endogenous/biological factors?
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How does such individual variability help us understand
general population variability, sensitive
subpopulations and related risks?
-
What does the public need to understand about the
implications of such individual variability, and how
could/should the public health and risk assessment
community start addressing this need?
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